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Water: 100 mg/mLwarmed(134
InChi: InChI=1S/C14H20Br2N2
8-fold increase in GPR120 mRNA expression
CAS Number: 1228280-29-2
7H-pyrazolo[4
PF-5274857 773 Water: 100 mg/mLwarmed(134PF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for